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    Benefits of Citrulline and Whether It’s Safe to Take

    Citrulline (l-citrulline) is a nonessential amino acid that offers several benefits.

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    • For example, it helps the body eliminate harmful substances such as ammonia, may have antioxidant effects, and acts as a vasodilator, widening the blood vessels. It's also promoted to improve athletic performance and enhance heart health, but research on effectiveness is limited.

    Citrulline is made in the liver and intestine, consumed in foods such as watermelon and cucumbers, and available as a dietary supplement.

    In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says.

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    When choosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.

    What Are the Benefits of Citrulline?

    Citrulline is naturally produced in the body, even if you do not consume it.

    Upon ingestion, citrulline breaks down into

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